nkhani

Pamene dihydrotanshinone ndimapha Helicobacter pylori, sichingowononga biofilm, komanso kupha mabakiteriya omwe amakhala ndi biofilm, yomwe imathandizira "kuzula" Helicobacter pylori.

Bi Hongkai, Pulofesa, School of Basic Medicine, Nanjing Medical University

Malipoti aposachedwa kwambiri a khansa yapadziko lonse lapansi akuwonetsa kuti pakati pa mamiliyoni a 4.57 miliyoni a khansa ku China chaka chilichonse, 480,000 yatsopano ya khansa ya m'mimba, yowerengera 10.8%, ndi ena mwa atatu apamwamba. Ku China komwe kumachitika matenda a khansa ya m'mimba, kuchuluka kwa matenda a Helicobacter pylori ndikokwanira 50%, ndipo vuto la kukana kwa maantibayotiki likukulirakulira, zomwe zimapangitsa kuti kuchepa kutheretu.
Posachedwa, gulu la Pulofesa Bi Hongkai, School of Basic Medicine, Nanjing Medical University, idasanthula munthu watsopano wogwiritsa ntchito mankhwala osokoneza bongo a Helicobacter pylori-Dihydrotanshinone I. Dihydrotanshinone Ndili ndi mwayi wothandiza kwambiri komanso kupha mwachangu Helicobacter pylori, anti - Helicobacter pylori biofilm, chitetezo ndi kukana kukana, ndi zina zambiri, ndipo akuyembekezeka kuti azichita kafukufuku wothandizidwa ngati anti-Helicobacter pylori ofuna mankhwala. Zotsatirazi zidasindikizidwa pa intaneti m'magazini ovomerezeka apadziko lonse lapansi a "Antimicrobial Agents and Chemotherapy".

Njira yoyamba yolephera kuchipatala ndi pafupifupi 10%

Pansi pa microscope, kutalika ndi ma 2.5 micrometer mpaka 4 micrometer, ndipo m'lifupi mwake ndi ma micrometer a 0,5 mpaka 1 micrometer. Helicobacter pylori, mabakiteriya ozungulira mwauzimu omwe "amafalitsa mano ndi kuvina zikhadabo", sangangoyambitsa zilonda zam'mimba komanso zamatenda, zilonda zam'mimba ndi zam'mimba ndi ma lymphatics. Matenda monga kufalikira kwa gastric lymphoma amakhalanso okhudzana ndi khansa ya m'mimba, khansa ya chiwindi, ndi matenda ashuga.

Mankhwala opatsirana katatu komanso anayi omwe amakhala ndi maantibayotiki awiri amagwiritsidwa ntchito mdziko langa pochiza Helicobacter pylori, koma njira zamankhwala zochiritsira sizingathetse Helicobacter pylori.

“Kulephera kwa chithandizo choyamba cha mankhwala achikhalidwe ndi pafupifupi 10%. Odwala ena amatsekula m'mimba kapena matenda am'mimba. Zina zimakhala zosavomerezeka ndi penicillin, ndipo pali maantibayotiki ochepa omwe mungasankhe. Nthawi yomweyo, kugwiritsa ntchito maantibayotiki kwa nthawi yayitali kumayambitsa mabakiteriya Kukula kwa mankhwala osokoneza bongo kumapangitsa mphamvu ya maantibayotiki kukhala yayikulu kwambiri, ndipo zotsatira zake sizingatheke. ” Bi Hongkai adati: "Mabakiteriya samagonjetsedwa ndi maantibayotiki ena, komanso amalimbana ndi maantibayotiki ena, ndipo mankhwalawa amatha kusintha mosiyanasiyana. Tizilombo toyambitsa matenda timafalikira kudzera mwa majini osamva mankhwala, zomwe zimapangitsa kuti mabakiteriya asamamwe mankhwala. ”

Helicobacter pylori ikalimbana ndi kuwukira kwa adani, mochenjera imapanga biofilm "chophimba chotetezera" pawokha, ndipo biofilm imatha kulimbana ndi maantibayotiki, zomwe zimapangitsa kuti Helicobacter pylori iwonjezeke, zomwe zingakhudze zotsatira zake zochiritsira ndikuchepetsa Mlingo wa machiritso.

Salvia miltiorrhiza kuyesa kwa cell kumatha kulepheretsa mitundu yambiri yosagwiritsa ntchito mankhwala

Mu 1994, World Health Organisation idasankha Helicobacter pylori ngati khansa ya m'kalasi yoyamba chifukwa imathandizira pakuwonekera ndi kukulitsa khansa ya m'mimba. Momwe mungathetsere wopha anthuwa? Mu 2017, gulu la Bi Hongkai lidachita zoyeserera zoyambirira-Danshen.

Danshen ndi amodzi mwamankhwala achikhalidwe achi China omwe amagwiritsidwa ntchito kwambiri popititsa patsogolo magazi komanso kuchotsa ma stasis amwazi. Zomwe zimasungunuka mafuta ndizosakanikirana ndi tanshinone, kuphatikiza ma monomers opitilira 30 monga tanshinone I, dihydrotanshinone, tanshinone IIA, ndi cryptotanshinone. Mankhwala a Tanshinone ali ndi zovuta zosiyanasiyana zamankhwala, monga anti-khansa, mabakiteriya odana ndi zotupa, odana ndi zotupa, zochitika ngati estrogen ndi chitetezo cha mtima, ndi zina zambiri, koma anti-Helicobacter pylori zotsatira sizinafotokozedwe.

"M'mbuyomu, tidasanthula ma monomers opitilira 1 000 aku China pamaselo, kenako tidazindikira kuti dihydrotanshinone I monomer ku Danshen idathandizira kwambiri kupha Helicobacter pylori. Tikamayesa maselo, tidapeza kuti kuchuluka kwa dihydrotanshinone komwe ndimagwiritsidwa ntchito Ikakhala 0.125 μg / ml-0.5 μg / ml, imatha kuletsa kukula kwa mitundu ingapo ya Helicobacter pylori, kuphatikiza mitundu yosamva mankhwala . ” Bi Hongkai adati dihydrotanshinone I imathandizanso motsutsana ndi Helicobacter pylori mu biofilms. Kupha kwabwino, ndipo Helicobacter pylori sanalimbane ndi dihydrotanshinone I panthawi yopitilira.

Chodabwitsa chachikulu ndichakuti "Dihydrotanshinone ndikapha Helicobacter pylori, imatha kungowononga biofilm, komanso kupha mabakiteriya omwe amakhala ndi biofilm, yomwe imathandizira 'kuzula' kwa Helicobacter pylori. "Bi Hongkai adayambitsa.

Kodi Dihydrotanshinone ndingachiritse Helicobacter pylori?

Pofuna kuti zotsatira zoyeserazi zikhale zolondola, gulu la Bi Hongkai lidawunikiranso zoyeserera mbewa kuti zidziwitse zakupha kwa dihydrotanshinone I pa Helicobacter pylori.

Bi Hongkai adawonetsa kuti poyeserera, patatha milungu iwiri mbewa zitapatsidwa kachilombo ka Helicobacter pylori, ofufuzawo adagawika m'magulu atatu, omwe ndi gulu loyang'anira la omeprazole ndi dihydrotanshinone I, gulu loyang'anira magawo atatu, ndi phosphoric acid In gulu lowongolera, mbewa zimapatsidwa mankhwala kamodzi patsiku kwa masiku 3 motsatizana.

"Zotsatira zoyesera zikuwonetsa kuti gulu loyang'anira limodzi la omeprazole ndi dihydrotanshinone I ndikotheka kupha Helicobacter pylori kuposa gulu lomwe limayikidwa katatu." Bi Hongkai adati, zomwe zikutanthauza kuti mu mbewa, dihydrotanshinone ndili ndi kupha kochulukirapo kuposa mankhwala amwambo.

Kodi Dihydrotanshinone ndingalowe m'nyumba za anthu wamba? Bi Hongkai adatsimikiza kuti Danshen sangagwiritsidwe ntchito mwachindunji kuteteza ndi kuchiza matenda a Helicobacter pylori, ndipo monomer yake dihydrotanshinone I ikadali kutali kuti ipangidwe ngati mankhwala omwe angagwiritsidwe ntchito kuchipatala. Anatinso kuti gawo lotsatira lipitiliza kuphunzira momwe dihydrotanshinone I imagwirira ntchito, ndikukonzanso mankhwala ndi mankhwala a dihydrotanshinone I motsutsana ndi Helicobacter pylori. “Njira yomwe tidalowera ikadali yayitali. Ndikukhulupirira kuti makampani atha kutenga nawo mbali pazofufuza zachipatala zisanachitike ndikupitiliza kafukufukuyu kuti athandize odwala ambiri omwe ali ndi matenda am'mimba. ”